Impact of proteogenomic evidence on clinical success

Karim, M. A., Hukku, A., Ariano, B., Holzinger, E., Tsepilov, Y., Hayhurst, J., Buniello, A., McDonagh, E. M., Castel, S. E., Nelson, M. R., et al.

10.64898/2026.02.23.26346731 · was preprinted

biomedical

Surfaced because: matches the platform's topic region.

relevance 0.36 openness 0.00 novelty 0.44

Abstract

We assessed the impact of plasma protein quantitative trait loci (pQTL) on genetically supported therapeutic hypotheses. We show that pQTL-supported target-indication pairs were 4.4 times more likely to advance from Phase I to launch, compared to a 2.6-fold increase observed with other human genetic evidence. Moreover, pQTL-based enrichment was prominent in druggable protein families which had limited enrichment from other genetic evidence sources.

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medrxiv v3 2026-10-20 source ↗

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