865 in the window; the type tabs sum to fewer β some papers are unclassified.
A Chemically Defined Synthetic Cell Capable Of Growth And Replication
1d ·
Gaut, N. J., Deich, C., Cash, B., et al.
· biorxiv
top 1% discussedtop 1% novel
Surfaced because: unusual independent discussion.
π¬ 11 discussion
Bacterial Hsp70 DnaK transiently samples the proteome to rapidly capture stress-induced misfolding
1d ·
Pajari, A., Redchuk, T., MaΜkelaΜ, J.
· biorxiv
discovery
top 2% discussedtop 6% novel
Surfaced because: unusual independent discussion.
π¬ 4 discussion
Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition
1d ·
Gonzaga-Saavedra, N., Degen, E. A., Soluri, I. V., et al.
· biorxiv
discovery
top 2% discussed
Surfaced because: unusual independent discussion.
π¬ 5 discussion
Cellular Stress Tolerance Governs Genetic Transformability in Recalcitrant Candida Species
1d ·
Cotter, C. J., Carper, D. L., Giannone, R. J., et al.
· biorxiv
discovery
top 1% novel
Surfaced because: novel vs its neighbours.
Targeted DNA nicking enables efficient, single-step and counterselection-free editing of bacteriophage genomes
1d ·
Englert, F., Valappil, S. K., Kubilius, J., et al.
· biorxiv
discovery
top 8% novel
Surfaced because: matches the platform's topic region.
π¬ 2 discussion
EZSolver: Template-free prediction of polar enzymatic mechanisms via bidirectional flow matching and search
1d ·
Kuo, L.-H., Yang, J., Arnold, F.
· biorxiv
method development
benchmarked
top 6% novel
Surfaced because: benchmarked against baselines.
π¬ 3 discussion
Planetary-scale heterotrophic microbial community modeling assesses metabolic synergy and viral impacts
1d ·
Regimbeau, A., Tian, F., Smith, G., et al.
· biorxiv
method development
benchmarked
Surfaced because: benchmarked against baselines.
π¬ 1 discussion
Hematopoietic stem cells undergo bidirectional fate transitions in vivo
2d ·
Fukushima, T., Kristiansen, T. A., Wong, L. P., et al.
· biorxiv
top 2% discussedtop 2% novel
Surfaced because: unusual independent discussion.
π¬ 2 discussion
SMAD4 MH2 Mutations Disrupt CREBBP/EP300 Recruitment and TGF-Ξ²-Induced Transcription in Colorectal Cancer
1d ·
Islam, M. S., Nizamuddin, S., Haw Chan, T. E., et al.
· biorxiv
top 2% novel
Surfaced because: matches the platform's topic region.
π¬ 3 discussion
Rapid and efficient oligodendrocyte differentiation from human pluripotent stem cells via dual inhibition of BMP and Notch signaling
1d ·
Evangelisti, A., Phillips, S. M., Jungverdorben, J., et al.
· biorxiv
top 3% novel
Surfaced because: matches the platform's topic region.
Rectangle: robust and scalable multiscale deconvolution informed by single-cell RNA sequencing data
1d ·
Eder, B., Rigato, I., Dietrich, A., et al.
· biorxiv
method development
benchmarked
Surfaced because: unusual independent discussion, benchmarked against baselines.
π¬ 3 discussion
Machine learning guided cell-free expression maps the biochemical landscape of carbonic anhydrase
2d ·
Lazar, J. T., Komp, E., Martinez, I., et al.
· biorxiv
method development
benchmarked
top 9% novel
Surfaced because: unusual independent discussion, benchmarked against baselines.
π¬ 4 discussion
MicroGrowAgents: An Agentic AI System for Microbial Cultivation Engineering
1d ·
Naseem, S., Miller, M. A., Martinez-Gomez, N. C., et al.
· biorxiv
method development
top 3% novel
Surfaced because: matches the platform's topic region.
scJET: Full-gene Space Single-cell Expression Generation with Patch-based Transformer Modeling
1d ·
Liang, Q., Lyu, Q. R.
· biorxiv
method development
Surfaced because: matches the platform's topic region.
π¬ 2 discussion
Lineage specifying transcription factors determine cell function by direct control of metabolism
1d ·
Bott, A. J., Youngs, J. C., Cunningham, C. N., et al.
· biorxiv
top 2% novel
Surfaced because: matches the platform's topic region.
π¬ 2 discussion
Retrotransposons Promote Dnmt3a-Mutant Clonal Hematopoiesis Through Aging-Related Stromal Inflammation
1d ·
Zhang, Q., Hu, W., Theriot, J., et al.
· biorxiv
top 2% novel
Surfaced because: matches the platform's topic region.
Synergistic CRISPR-Cas Antimicrobials through Essential and Defensive Gene Cotargeting in Staphylococcus aureus
1d ·
Dooley, D. S., Trinh, C. T.
· biorxiv
discovery
benchmarked
top 7% novel
Surfaced because: benchmarked against baselines.
π¬ 2 discussion
A new genome-scale model enables prediction of cancer metabolic dependencies
1d ·
Dinh, H. V., Zoitou, A., Zhang, J., et al.
· biorxiv
Surfaced because: matches the platform's topic region.
The Aorta-Gonad-Mesonephros niche shapes the functions of yolk sac-derived macrophages involved in hematopoietic stem and progenitor cell generation ex vivo
1d ·
Belmonte, R. L., Romano, M., Popravko, A., et al.
· biorxiv
top 7% novel
Surfaced because: matches the platform's topic region.
Hoxb5 Enriches Long-Term Hematopoietic Stem Cell Activity within the Mouse Fetal Liver Phenotypic HSC Compartment
1d ·
Mascetti, V. L., Banuelos, A., Teague, K., et al.
· biorxiv
top 10% discussed
Surfaced because: unusual independent discussion.
π¬ 3 discussion
CRISPR-Mediated Linearization of IDLV Donor Enables Precise Targeted Integration in Human Hematopoietic Stem Cells
2d ·
Scalisi, G., Sakkal, A., Lacombe, L., et al.
· biorxiv
discovery
top 6% novel
Surfaced because: matches the platform's topic region.
π¬ 2 discussion
SpliSync: Genomic language model-driven splice site correction of long RNA sequencing reads
4d ·
Lui, W. W., Florea, L. D.
· biorxiv
method development
code
benchmarked
top 3% open
Surfaced because: unusual independent discussion, open code, benchmarked against baselines.
π¬ 4 discussion
A genetically encoded local learning rule enables physical learning in engineered bacteria
2d ·
Prakash, S., Varela, C., Walsh, M., et al.
· biorxiv
method development
top 5% novel
Surfaced because: unusual independent discussion.
π¬ 4 discussion
DSCAM preserves neuronal order during radial migration by antagonizing N-Cadherin adhesion and UNC5c repulsion
1d ·
Yang, T., Hergenreder, T., Veling, M. W., et al.
· biorxiv
top 4% novel
Surfaced because: matches the platform's topic region.
VicMAG, an open-source tool for visualizing circular metagenome-assembled genomes highlighting bacterial virulence and antimicrobial resistance
1d ·
Tsuda, Y., Tanizawa, Y., Vu, T. M. H., et al.
· biorxiv
method development
top 10% novel
Surfaced because: matches the platform's topic region.
Coding agents author interpretable single-cell embedding models from the literature
1d ·
Brunn, N., Krissmer, S. M., Frosch, M., et al.
· biorxiv
method development
benchmarked
Surfaced because: unusual independent discussion, benchmarked against baselines.
π¬ 2 discussion
Phenotypic CRISPR screening identifies ZBTB10 as a novel regulator of human trophoblast differentiation
1d ·
Esbin, M. N., Bhowmik, R., Li, H., et al.
· biorxiv
Surfaced because: unusual independent discussion.
π¬ 3 discussion
Mechanochemical Feedback Enables Efficient Navigation in Complex Chemical Gradients
1d ·
Huras, E., Algorta, J., De Belly, H., et al.
· biorxiv
discovery
top 5% novel
Surfaced because: matches the platform's topic region.
Engineered probiotic Escherichia coli-mediated intestinal nicotine clearance alleviates nonalcoholic steatohepatitis in mice
1d ·
Zuo, N., Cai, X., Wang, W., et al.
· biorxiv
top 1% novel
Surfaced because: matches the platform's topic region.
π¬ 2 discussion
Morphospace analysis reveals divergent cellular behaviours driving tissue internalisation during insect gastrulation
1d ·
Battistara, M., PoΜnisch, W., Benton, M. A., et al.
· biorxiv
top 4% novel
Surfaced because: matches the platform's topic region.
π¬ 2 discussion