Rising — Salient

Bacterial Hsp70 DnaK transiently samples the proteome to rapidly capture stress-induced misfolding

1d · Pajari, A., Redchuk, T., Mäkelä, J. · biorxiv

discovery top 2% discussedtop 6% novel

Surfaced because: unusual independent discussion.

💬 4 discussion

Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition

1d · Gonzaga-Saavedra, N., Degen, E. A., Soluri, I. V., et al. · biorxiv

discovery top 2% discussed

Surfaced because: unusual independent discussion.

💬 5 discussion

Cellular Stress Tolerance Governs Genetic Transformability in Recalcitrant Candida Species

1d · Cotter, C. J., Carper, D. L., Giannone, R. J., et al. · biorxiv

discovery top 1% novel

Surfaced because: novel vs its neighbours.

Targeted DNA nicking enables efficient, single-step and counterselection-free editing of bacteriophage genomes

1d · Englert, F., Valappil, S. K., Kubilius, J., et al. · biorxiv

discovery top 8% novel

Surfaced because: matches the platform's topic region.

💬 2 discussion

Synergistic CRISPR-Cas Antimicrobials through Essential and Defensive Gene Cotargeting in Staphylococcus aureus

1d · Dooley, D. S., Trinh, C. T. · biorxiv

discovery benchmarked top 7% novel

Surfaced because: benchmarked against baselines.

💬 2 discussion

CRISPR-Mediated Linearization of IDLV Donor Enables Precise Targeted Integration in Human Hematopoietic Stem Cells

2d · Scalisi, G., Sakkal, A., Lacombe, L., et al. · biorxiv

discovery top 6% novel

Surfaced because: matches the platform's topic region.

💬 2 discussion

Mechanochemical Feedback Enables Efficient Navigation in Complex Chemical Gradients

1d · Huras, E., Algorta, J., De Belly, H., et al. · biorxiv

discovery top 5% novel

Surfaced because: matches the platform's topic region.

Programmed DNA elimination was present in the last common ancestor of Caenorhabditis nematodes

2d · Stevens, L., Sun, S., Haruta, N., et al. · biorxiv

discovery top 1% discussed

Surfaced because: unusual independent discussion.

💬 5 discussion 👁 1 reader

Robust axis formation requires both short-range adhesion and long-range attraction

1d · Guan, G., Wang, S., Shields, T. G., et al. · biorxiv

discovery top 6% novel

Surfaced because: matches the platform's topic region.

3' Exonuclease-mediated DNA assembly at room temperature and below

2d · Irving, O. J., Khan, C. J., Albrecht, T. · biorxiv

discovery

Surfaced because: matches the platform's topic region.

USP7 maintains hematopoietic stem cell dormancy and function by stabilizing HMGA2

1d · Nouhaud, A., Diaz, A., Bouttier, M., et al. · biorxiv

discovery top 6% novel

Surfaced because: matches the platform's topic region.

💬 1 discussion

Regulation of RNA maturation by the family of human G-patch proteins

1d · Memet, I., Kanwal, N., Ritchie, A., et al. · biorxiv

discovery top 3% novel

Surfaced because: matches the platform's topic region.

Telomerase RNA regulates the epigenome primed for human lineage commitment

1d · Li, J., Su, P., Gao, M., et al. · biorxiv

discovery top 3% novel

Surfaced because: matches the platform's topic region.

Comparative characterization of Cas12a2 orthologs identifies high-activity nucleases for programmable cell elimination

3d · Singer, A. L., January, E. E., Zess, E. K., et al. · biorxiv

discovery top 5% novel

Surfaced because: matches the platform's topic region.

💬 2 discussion 👁 1 reader

FORGE-KI: A Modular Framework for Endogenous Knock-In Engineering Across HDR and PITCh/MMEJ Repair Pathways

2d · Conklin, D., Lee, J.-A., Palazzolo, M., et al. · biorxiv

discovery top 6% novel

Surfaced because: matches the platform's topic region.

💬 2 discussion

HSPB8 regulates CTP synthase filaments to couple nucleotide metabolism and autophagy in tumors

1d · Wang, C.-Y., Lin, W.-C., Huang, K.-J., et al. · biorxiv

discovery

Surfaced because: matches the platform's topic region.

💬 2 discussion

LINE-1 transposon derived DNA lesions reshape the chromatin landscape to promote genome instability

1d · Kumar, A., Parida, A. S., Kiran, K., et al. · biorxiv

discovery top 10% novel

Surfaced because: matches the platform's topic region.

Reprogramming a Protein Ligase for Genetic Code Expansion

2d · Gallo, G., Sieber, A., Hellwig, M., et al. · biorxiv

discovery top 3% novel

Surfaced because: matches the platform's topic region.

Circadian temperature compensation is intrinsically linked with metabolism and redox signaling

2d · Xu, Y., Mori, T., Mehra, H., et al. · biorxiv

discovery top 2% novel

Surfaced because: matches the platform's topic region.

A cinnamyl alcohol dehydrogenase-like scaffold organizes monoterpenoid indole alkaloid biosynthesis

1d · Gao, D., Alexander Mann, S. G., Chen, B., et al. · biorxiv

discovery top 8% novel

Surfaced because: matches the platform's topic region.

Centrosome Migration and Apical Membrane Formation in Polarized Epithelial Cells: Insights from the MDCK Cyst Model

1d · Wang, P.-K., Lin, K.-h., Tang, T. K. · biorxiv

discovery

Surfaced because: unusual independent discussion.

💬 3 discussion

The human leukemic fusion protein MLL-AF4 promotes autophagy and cell death in the fat body of Drosophila melanogaster

1d · Haukeland, A. L. C., Johannessen, J. A., Brathen, N. R., et al. · biorxiv

discovery top 6% novel

Surfaced because: matches the platform's topic region.

💬 2 discussion

Fast assembly and in vivo coalescence of ParBF biocondensates involved in bacterial DNA partition

1d · Revoil, P., Delimi, L., Rech, J., et al. · biorxiv

discovery

Surfaced because: matches the platform's topic region.

Stoichiometric transcription factor partnerships control GABAergic neuron fate allocation

2d · Dvoretskova, E., Lynch, C., Bright, A. R., et al. · biorxiv

discovery top 3% novel

Surfaced because: matches the platform's topic region.

Solid-like PAR protein assemblies encode long-term spatial memory of cell polarity during suspended animation

1d · Borrego-Pinto, J., Cornwall Scoones, J., Hirani, N., et al. · biorxiv

discovery

Surfaced because: matches the platform's topic region.

💬 2 discussion

Impact of coding region accessibility and uridine chemistry on translation in mRNA-DNA hybrid origami

1d · DAmico, C., Mykkänen, M., Saarinen, S., et al. · biorxiv

discovery

Surfaced because: matches the platform's topic region.

💬 2 discussion

Aberrant 3'UTR splicing drives FUS-dependent mRNA condensates and prevents β-catenin from adherens junctions to promote cancer aggressiveness

1d · Hong, D., Kim, N., Jo, Y., et al. · biorxiv

discovery top 8% novel

Surfaced because: matches the platform's topic region.

💬 2 discussion

RNA dysregulation and compromised neuronal identity drive pathogenesis in Senataxin-associated ALS

1d · Giannini, M., Gostan, T., El Aabidine, A. Z., et al. · biorxiv

discovery top 7% discussed

Surfaced because: unusual independent discussion.

💬 2 discussion

Single-molecule imaging reveals cytoplasmic translation of P granule-enriched mRNAs in C. elegans

1d · Simmons, W. R., Geng, Q., Miller, S. I., et al. · biorxiv

discovery

Surfaced because: matches the platform's topic region.

💬 2 discussion

Sequence determinants of efficient exon 44 skipping in Duchenne muscular dystrophy define design principles for steric-blocking antisense oligonucleotides

1d · Han, E., Webster, K., Stan, T. L., et al. · biorxiv

discovery benchmarked

Surfaced because: benchmarked against baselines.