Rising — Salient

Curating MitoCore: A Standardized Small-Scale Human Metabolic Model as Platform for Proteomics Integration and Disease Modeling

1d · Lange, E., Santamaria, A. B. R., Heyer, R. · biorxiv

biomedical code

Surfaced because: open code.

Toward pharmacologic therapy for glioblastoma: Characterization of the very long-chain acyl-CoA synthetase 3 (ACSVL3) inhibitor Grassofermata

2d · Clay, E. M., Shi, X., Kolar, E. A., et al. · biorxiv

biomedical top 1% novel

Surfaced because: matches the platform's topic region.

Liver microbiome composition associates with histological severity and PNPLA3 genotype in metabolic dysfunction-associated steatotic liver disease

1d · Mascardi, M. F., Taussig, R., Signoretta, I. P., et al. · biorxiv

biomedical top 6% novel

Surfaced because: matches the platform's topic region.

Slc25a34-Mediated Mitochondrial-to-Cytoplasmic AMP Transport Activates Brown Adipose Tissue Thermogenesis

1d · Long, Y., Yang, X., Zhou, J., et al. · biorxiv

biomedical top 10% novel

Surfaced because: matches the platform's topic region.

Diet links gut chemistry with cancer risk in C57Bl/6 mice and human colorectal cancer patients

1d · Cohen, Z., Choi, J., Peregrina, K., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

💬 2 discussion

A Paracrine Dietary Lipid Axis Constrains Antitumor Immunity in Liver Cancer

1d · Ciobu, N., Kumari, R., Kumar, J. S., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

💬 1 discussion

Hepatobiliary Progenitor-like Reprogramming in Liver Metastases

1d · Sharma, A. K., Takahashi, N., Cao, Y., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

S100A9-Dependent CXCR2hi Neutrophils Mediate Systemic Immune Suppression and Checkpoint Resistance in Metastatic TNBC

2d · Koksalar Alkan, F., Caglayan, A. B., Alkan, H. K., et al. · biorxiv

biomedical

Surfaced because: unusual independent discussion.

💬 4 discussion

Anti-CAR Immunity Drives Acquired Therapeutic Resistance to GD2-CAR T Cell Therapy in Diffuse Midline Glioma

1d · Chen, Y., Reynolds, K., Koch, M. R. A., et al. · medrxiv

biomedical

Surfaced because: matches the platform's topic region.

💬 2 discussion

Hierarchical classification of hematologic malignancies using epigenetic and genetic information

1d · Schönung, M., Türe, M., Lajer, P., et al. · biorxiv

biomedical benchmarked

Surfaced because: benchmarked against baselines.

Quantifying target antigen-dependent CAR T-cell performance against AML

1d · Shah, S., Mueller, J., Vogel, E., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

Persistence of tobacco-mutated alveolar progenitor cells after smoking cessation mirrors long term risk of lung adenocarcinoma

1d · Przybilla, M. J., Ammar, A., Selway-Clarke, H., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

PACMOS: an R package for Projection And Classification of Multi-Omic Samples

3d · Kalson, L., Sexton-Oates, A., Drevet, G., et al. · biorxiv

biomedical code

Surfaced because: open code.

Multi-Tissue Metabolomic Signatures of Five Longevity Interventions Converge on Ergothioneine and Lipid Remodeling in Male UM-HET3 Mice

1d · Badenoch, B., Fiehn, O., Rappaport, N., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

The novel curcumin analogue AKT-100 targets both mutant p53 and STAT3 in gynecologic cancer cells

2d · Williams, G. L., Smith, L. E., Padilla, J. L., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

A Glutamine antagonist-modulated tumor microenvironment unleashes enzalutamides immunotherapeutic effects

1d · Yu, J., Jiang, X., Yao, H., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

Neutral Sphingomyelinase-2 Restrains TAZ to Suppress Breast Tumor Growth

1d · Resnick, A. E., Franzi, V., Ghandour, B. K., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

GALE-dependent glycoproteome remodelling is a determinant of oncogenic RAS transformation

2d · Stölting, F., Vesce, R., Rodriguez-Santana, C., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

Distinct colorectal cancer genotypes shape microbial ecosystems and reveal stage-specific microbiota dependencies

3d · Brunner, V., Bodenstein, N., Zaurito, A. E., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

💬 2 discussion 👁 1 reader

A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer

2d · Zheng, Y., Cheng, C., Cao, Y., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

💬 2 discussion

Oncogene-driven metabolic regulation of Dihydroceramide Desaturase 1 (DES1) converges on GAPDH in matrix-detached conditions

2d · Lambadis, D. L., Franzi, V., Peperno, D. M., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

Combined AMPK activation and ghrelin ameliorate cancer cachexia through complementary effects on energy homeostasis, inflammation, and wasting

2d · Gonzalez-Alvarez, V., Caamano, S., Reimundez, A., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

Phenotypic inference from sparse tumor genomes informs an explainable deep-learning model for cancer prognosis

9d · Grant, S., Nath, A. · biorxiv

biomedical benchmarked top 7% novel

Surfaced because: benchmarked against baselines.

💬 3 discussion

LsGCRPred: lncRNA-SNP regulated gene expression-based breast and ovarian cancer risk prediction model

3d · Das, T., Das, G., Ghosh, B., et al. · biorxiv

biomedical code

Surfaced because: open code.

💬 2 discussion

Systematic elucidation and pharmacologic targeting of non-oncogene dependencies in imatinib-resistant gastrointestinal stromal tumor

2d · Mundi, P. S., Grunn, A., Kojadinovic, A., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

Pan-Cancer Driver Mutation Signatures Define a Molecular Taxonomy of Tumors

2d · Huang, X., Chen, B., Huang, X., et al. · biorxiv

biomedical

Surfaced because: matches the platform's topic region.

FeatureMSEA: Metabolic Feature-based Metabolite Set Enrichment Analysis

3w · Liu, Y., Wang, Y., Huan, T., et al. · biorxiv

biomedical code data top 8% discussedtop 3% open

Surfaced because: unusual independent discussion, open code, data available.

💬 4 discussion

Integrating multi-ancestry common and rare variant mapping accelerates therapeutic target discovery

2d · Koyama, S., Nakao, T., Choi, S. H., et al. · medrxiv

biomedical

Surfaced because: matches the platform's topic region.

Prognostic Features of Anti-Cancer Drugs Response in Resected/Unresected Primary Non-Small Cell Lung Cancer: A Retrospective Cohort Study

3d · Samadder, S. · medrxiv

biomedical benchmarked

Surfaced because: benchmarked against baselines.

Shared potential metabolism trends in degraded soils and type 2 diabetes gut microbiomes

3w · Liddicoat, C., Eijkelkamp, B. A., Cavagnaro, T. R., et al. · biorxiv

biomedical top 1% novel

Surfaced because: matches the platform's topic region.

💬 1 discussion